Potassium Carbonate → HCID 11494407, compound

HRID 1878991Notes

Reaction equation

HRID 1878991 reaction equation
[F:1][C:2]1[C:7]([S:8]([C:11]([F:14])([F:13])[F:12])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:28][CH2:29][O:30][CH3:31]>C(#N)C>[F:1][C:2]1[C:7]([S:8]([C:11]([F:14])([F:13])[F:12])(=[O:9])=[O:10])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:15]1[CH2:20][CH2:19][N:18]([CH2:28][CH2:29][O:30][CH3:31])[CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 574480514-{2-Fluoro-3-[(trifluoromethyl)sulfonyl]phenyl}piperidine

Product 1

HCID 11494407HCID 11494407, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 4-{2-fluoro-3-[(trifluoromethyl)sulfonyl]phenyl}-piperidine (0.01 g), acetonitrile (2 ml), potassium carbonate (0.01 g) and 1-bromo-2-methoxyethane (0.01 g). MS m/z (rel. intensity, 70 eV) 369 (M+, 1), 325 (15), 324 (bp), 191 (37), 133 (14).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-f214d25567ea4f819eee15af3d7c7e5a
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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