反应详情

N-(3 Methoxyphenylsulfonyl)D-tert-leucine (3.03 g, 10.1 mmol) is dissolved in DMF (30 ml). Potassium Carbonate (2.81 g, 20.1 mmol) is added followed by Benzyl Bromide (1.21 ml, 9.95 mmol) and the reaction is stirred at ambient temperature for 18 hours. The reaction mixture is partitioned between Ethyl Acetate and 1 N HCl. The organics are separated and washed with brine, dried over MgSO4 and concentrated. The residue is purified by column chromatography eluting with a gradient of 5-60% (Hex-EtOAc) to give the title compound (3.08 g, 78% yield). Mass spectrum (392.2; M+1, 390.2; M−1).

1. customThe reaction mixture is partitioned between Ethyl Acetate and 1 N HCl
2. customThe organics are separated
3. washwashed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customThe residue is purified by column chromatography
7. washeluting with a gradient of 5-60% (Hex-EtOAc)