Lithium Hydroxide → HCID 58468020, compound

HRID 1879392Notes

Reaction equation

HRID 1879392 reaction equation
[OH-].[Li+].[C:3]([O:7][C:8]([NH:10][C@@H:11]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[C@H:15]([CH2:22][C:23]([O:25]CC)=[O:24])[CH2:14][CH2:13][C@H:12]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:29]=1[F:35])=[O:9])([CH3:6])([CH3:5])[CH3:4]>O1CCCC1.O>[C:3]([O:7][C:8]([NH:10][C@@H:11]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[C@H:15]([CH2:22][C:23]([OH:25])=[O:24])[CH2:14][CH2:13][C@H:12]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:29]=1[F:35])=[O:9])([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58468019HCID 58468019, compound

Product 1

HCID 58468020HCID 58468020, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of lithium hydroxide (11.2 mg, 0.468 mmol) and ethyl 2-((5S,6S,9S)-5-(tert-butoxycarbonylamino)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)acetate (27.8 mg, 0.060 mmol) in tetrahydrofuran (3 mL) and water (0.3 mL) was stirred at room temperature for 24 h. The solvent was removed via high vacuum and the crude product (MS(ESI)[M+H+]=433.17) was used as is in the next step.

Workup

  1. customThe solvent was removed via high vacuum

Sources & evidence

ORD record
ord-27fa313a66c74076bb617a2cdc62212c
Source dataset
uspto-grants-2012_11
Patent number
US08314117B2

Reaction notes

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