Lithium Hydroxide → HCID 58467985, compound

HRID 1879393Notes

Reaction equation

HRID 1879393 reaction equation
[OH-].[Li+].[C:3]([O:7][C:8]([NH:10][C@@H:11]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[C@@H:15]([CH2:22][C:23]([O:25]CC)=[O:24])[CH2:14][CH2:13][C@H:12]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:29]=1[F:35])=[O:9])([CH3:6])([CH3:5])[CH3:4]>O1CCCC1.O>[C:3]([O:7][C:8]([NH:10][C@@H:11]1[C:21]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[C@@H:15]([CH2:22][C:23]([OH:25])=[O:24])[CH2:14][CH2:13][C@H:12]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([F:34])[C:29]=1[F:35])=[O:9])([CH3:6])([CH3:4])[CH3:5]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58467995HCID 58467995, compound

Product 1

HCID 58467985HCID 58467985, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of lithium hydroxide (11.2 mg, 0.468 mmol) and ethyl 2-((5S,6S,9R)-5-(tert-butoxycarbonylamino)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)acetate (118.1 mg, 0.256 mmol) in tetrahydrofuran (3 mL) and water (0.3 mL) was stirred at room temperature over night. LCMS showed complete conversion. The reaction was dried under high vacuum and the crude product (MS(ESI)[M+H+]=433.17) was used as is in the next step.

Workup

  1. customThe reaction was dried under high vacuum

Sources & evidence

ORD record
ord-97161e0aec39462badbd24152b75ff76
Source dataset
uspto-grants-2012_11
Patent number
US08314117B2

Reaction notes

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