Lithium Hydroxide → HCID 58123101, compound

HRID 1880382Notes

Reaction equation

HRID 1880382 reaction equation
[CH2:1]([C:3]1[C:11]2[C:6](=[C:7]([O:17][CH3:18])[CH:8]=[C:9]([C:12]([O:14]CC)=[O:13])[CH:10]=2)[N:5]([CH3:19])[N:4]=1)[CH3:2].[Li+].[OH-]>C1COCC1>[CH2:1]([C:3]1[C:11]2[C:6](=[C:7]([O:17][CH3:18])[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[CH:10]=2)[N:5]([CH3:19])[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66920633HCID 66920633, compound

Product 1

HCID 58123101HCID 58123101, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of ethyl 3-ethyl-7-methoxy-1-methyl-1H-indazole-5-carboxylate (52 mg, 0.20 mmol) in THF (1.5 mL) was added 1 M LiOH (0.36 mL, 0.36 mmol). The mixture was heated at reflux overnight. The reaction was cooled to room temperature, concentrated, triturated with 1 N HCl, the filtered solids were then washed with water and air dried to provide the title compound (46 mg, 94%).

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux overnight
  3. concentrationconcentrated
  4. customtriturated with 1 N HCl
  5. washthe filtered solids were then washed with water and air
  6. customdried

Sources & evidence

ORD record
ord-5d1a8280b20e4ecfbb90c79c09c8e1c7
Source dataset
uspto-grants-2012_11
Patent number
US08318762B2

Reaction notes

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