Acetic Acid → HCID 67094460, compound

HRID 1881193Notes

Reaction equation

HRID 1881193 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][O:6][C:7]1[CH:12]=[C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:10]([O:21][CH3:22])=[CH:9][C:8]=1[CH:23]=O)[CH3:2].N12CCCN=C1CCCCC2.C(O)(=O)C>CN(C)C=O>[CH2:1]([O:3][C:4]([C:5]1[O:6][C:7]2[CH:12]=[C:11]([O:13][CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:10]([O:21][CH3:22])=[CH:9][C:8]=2[CH:23]=1)=[O:25])[CH3:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 86633442HCID 86633442, compound

Product 1

HCID 67094460HCID 67094460, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

(5-Benzyloxy-2-formyl-4-methoxyphenoxy)acetic acid ethyl ester (1.5 g), 1,8-diazabicyclo[5.4.0]undec-7-ene (0.33 g) and acetic acid (0.026 g) in N,N-dimethylformamide (8 ml) were stirred at 100° C. under nitrogen for 5 hours. After cooling to room temperature the mixture was poured in ice water and the precipitate was filtered.

Workup

  1. filtrationthe precipitate was filtered

Sources & evidence

ORD record
ord-88dfafeaa38040b99c891fadf717b2a2
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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