反应详情

To a solution of 6-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridine-3-carboxylic acid (0.205 g) in N,N-dimethylformamide (5 mL) were added 1-amino-2-methyl-propan-2-ol (76 mg), triethylamine (0.18 mL), N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (123 mg) and 1-hydroxybenzotriazole (98 mg), and the mixture was stirred at room temperature for 16 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by basic silica gel column 15 chromatography (ethyl acetate:hexane=40:60-100:0, volume ratio) and recrystallized from hexane-ethyl acetate to give the title compound (0.126 g, yield 53%) as colorless crystals. MS: 552 (MH+). melting point 126-128° C.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed successively with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by basic silica gel column 15 chromatography (ethyl acetate:hexane=40:60-100:0, volume ratio)
6. customrecrystallized from hexane-ethyl acetate