Cesium carbonate → 5-(3-(ethylsulfonyl)phenyl)-3-methyl-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indole

HRID 1882253Notes

Reaction equation

HRID 1882253 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH:13]2[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]2)=[C:7]2[C:3]=1[C:4]1[CH:23]=[C:22]([CH3:24])[CH:21]=[N:20][C:5]=1[NH:6]2.[CH2:25]([S:27]([C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[CH:34][CH:35]=1)(=[O:29])=[O:28])[CH3:26].C1(P(C2CCCCC2)C2CCCCC2)CCCCC1.C([O-])([O-])=O.[Cs+].[Cs+]>CCOC(C)=O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].O1CCOCC1>[CH2:25]([S:27]([C:30]1[CH:35]=[C:34]([C:2]2[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]3)=[C:7]3[C:3]=2[C:4]2[CH:23]=[C:22]([CH3:24])[CH:21]=[N:20][C:5]=2[NH:6]3)[CH:33]=[CH:32][CH:31]=1)(=[O:28])=[O:29])[CH3:26]

Participants

8

Reactant 4

HCID 10796Cesium carbonateHCID 75806TricyclohexylphosphineHCID 164271023-Ethylsulfonylphenylboronic acidHCID 588801545-chloro-3-methyl-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indole

Product 1

HCID 588800825-(3-(ethylsulfonyl)phenyl)-3-methyl-8-((1-methylpiperidin-4-yl)methoxy)-9H-pyrido[2,3-b]indoleYield 75.2%

Reagents, catalysts & solvents 3

HCID 6505921(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladiumCatalystHCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
125 °C

Procedure

To a stirred solution of Compound 175 (170 mg, 0.49 mmol) and 3-(ethylsulfonyl)phenylboronic acid (265 mg, 1.24 mmol) in anhydrous and degassed dioxane (5 mL), were added Pd(dba)2 (70 mg, 0.12 mmol), PCy3 (0.34 mL, 20% wt solution in toluene, 0.24 mmol) and Cs2CO3 (479 mg, 1.47 mmol), under nitrogen. After being stirred for 6 h. under reflux (oil bath temperature 125° C.) the reaction was diluted with EtOAc and filtered through a small pad of celite. The residue was washed thoroughly with EtOAc and 10% MeOH in CH2Cl2. All the washings and filtrate were concentrated in vacuum and the crude residue was triturated with ether and then with MeOH and then purified through preparative HPLC to give Compound 176 (176 mg, 75%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (t, J=7.34 Hz, 3H) 1.50-1.61 (m, 2H) 2.18 (br. s., 1H) 2.13-2.20 (m, 1H) 2.23-2.31 (m, 5H) 2.82 (s, 3H) 2.98-3.09 (m, 2H) 3.39 (q, J=7.34 Hz, 2H) 3.54 (d, J=10.60 Hz, 2H) 4.12 (d, J=6.52 Hz, 2H) 7.06-7.17 (m, 2H) 7.53 (s, 1H) 7.85 (t, J=7.74 Hz, 1H) 7.96 (d, J=7.66 Hz, 1H) 8.00 (d, J=7.66 Hz, 1H) 8.06 (s, 1H) 8.28 (d, J=1.47 Hz, 1H) 11.83 (br. s., 1H), [M+H] calc'd for C27H32N3O3S, 478.2; found, 478.4; [M+H+TFA] calc'd for C29H33N3O5F3S, 592.2; found, 592.4.

Workup

  1. filtrationfiltered through a small pad of celite
  2. washThe residue was washed thoroughly with EtOAc and 10% MeOH in CH2Cl2
  3. concentrationAll the washings and filtrate were concentrated in vacuum
  4. customthe crude residue was triturated with ether
  5. customwith MeOH and then purified through preparative HPLC

Sources & evidence

ORD record
ord-0f9363fc229441038be649020402e620
Source dataset
uspto-grants-2012_11
Patent number
US08318939B2

Reaction notes

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