Hydrochloric Acid → 1-(2-aminophenyl)propan-1-one

A 2.0N solution of ethylmagnesium chloride in THF (100 ml) was cooled to 0° C. under nitrogen atmosphere, and thereto was added dropwise a solution of 2-cyanoaniline (7.90 g) in THF (65 ml) over a period of 50 minutes. The mixture was stirred at room temperature for 20 minutes, and refluxed for 3 hours. The reaction solution was cooled to 0° C., and thereto was added a 4N aqueous hydrochloric acid solution (80 ml) over a period of 40 minutes, and the mixture was further refluxed for 3 hours. The solvent in the reaction solution was evaporated under reduced pressure, and the resultant was added to a saturated aqueous sodium hydrogen carbonate solution for neutralization. The mixture was extracted three times with ethyl acetate, and the extract was washed with a saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column (hexane/ethyl acetate=8/1) to give 1-(2-aminophenyl)-1-propanone (6.78 g, 68%).

1. temperaturerefluxed for 3 hours
2. temperatureThe reaction solution was cooled to 0° C.
3. temperaturethe mixture was further refluxed for 3 hours
4. customThe solvent in the reaction solution was evaporated under reduced pressure
5. additionthe resultant was added to a saturated aqueous sodium hydrogen carbonate solution for neutralization
6. extractionThe mixture was extracted three times with ethyl acetate
7. washthe extract was washed with a saturated brine
8. dry with materialdried over magnesium sulfate
9. filtrationfiltered
10. customThe solvent was evaporated under reduced pressure
11. customthe residue was purified by silica gel column (hexane/ethyl acetate=8/1)

ORD record

ord-3fb89612c1cf4fd2bf60e5b428434d32

Source dataset

uspto-grants-2004_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06759429B2