Triethylamine → HCID 86587026, compound

HRID 1883939Notes

Reaction equation

HRID 1883939 reaction equation
[CH:1]12[CH2:7][CH:4]([CH:5]=[CH:6]1)[CH2:3][CH:2]2[C:8]([OH:10])=[O:9].C(N(CC)CC)C.ClC[O:20][CH2:21][CH3:22]>C1COCC1>[CH:1]12[CH2:7][CH:4]([CH:3]=[CH:2]1)[CH2:5][CH2:6]2.[CH3:22][CH2:21][O:20][CH2:2][C:8]([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 18523Chloromethyl ethyl etherHCID 789495-Norbornene-2-carboxylic acid

Product 1

HCID 86587026HCID 86587026, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1 mol of 5-norbornene-2-carboxylic acid was dissolved in 1.5 l of THF, and 1.1 mol of triethylamine and 1.1 mol of chloromethylethylether were added thereto. The reaction was carried out at room temperature for 6 hours. After completion of the reaction, the resultant mixture was distilled under reduced pressure to provide 5-norbornene-2-ethoxymethylcarboxylate (ANCA) in 89% yield.

Workup

  1. customAfter completion of the reaction
  2. distillationthe resultant mixture was distilled under reduced pressure

Sources & evidence

ORD record
ord-0aa577e944d746daa449f8efd5df18c6
Source dataset
uspto-grants-2004_07
Patent number
US06762268B2

Reaction notes

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