Water → 2-Methoxybiphenyl

In the drybox, 110 mg (0.609 mmol) of (Me3C)2P—Cl, 67 mg (0.299 mmol) of Pd(OAc)2 and 3.0 mL of CH2Cl2 were loaded into a reactor (10 mL) equipped with a magnetic stir bar. The resulting mixture was stirred at room temperature for 4 h before 60 mg (3.3 mmol) of H2O was added. The mixture above was stirred at room temperature for 12 h. After removal of solvent and excess H2O, the residue was dissolved in 15.0 mL of 1,4-dioxane, and transferred into a reactor (100 mL). Next, 2-chloroanisole (1.43 g, 10.0 mm), C6H5B(OH)2 (1.83 g, 15.0 mm) and CsF (4.56 mg, 30.0 mmol) were added into the mixture above. After the mixture was refluxed for 42 h, the reaction mixture was then cooled to room temperature, quenched with 50 mL of H2O, and extracted with 300 mL of diethyl ether. The organic extracts were washed with H2O (2×50 mL), brine (50 mL), and dried over mgSO4, filtered, and the ether and dioxane removed from the filtrate by rotary evaporation. The resulting residue was chromatographed on silicon gel using hexane as eluant. The eluate was concentrated by rotary evaporation followed by high vacuum to give 1.81 g (98% yield) of 2-phenylanisole. It was >95% pure by 1H NMR and GC/MS. 1H NMR (500 MHz, CDCl3): δ7.85 (d, J=7.05 Hz, 2H), 7.67 (m, 2H), 7.60 (m, 3H), 7.32 (m, 1H), 7.22 (m, 1H), 4.01 (s, 3H) ppm. 13C NMR (125 MHz, CDCl3): δ156.4, 138.5, 130.7, 130.6, 129.4, 128.5, 127.8, 126.7, 120.7, 111.2, 55.3 ppm. HRMS Calcd for C13H12O: 185.0966. Found 185.0965. Anal. Calcd for C13H12O: C, 84.75; H, 6.57; O, 8.68. Found: C, 84.62; H, 6.65; O, 8.58.

1. custom(10 mL) equipped with a magnetic stir bar
2. additionwas added
3. customAfter removal of solvent and excess H2O
4. dissolutionthe residue was dissolved in 15.0 mL of 1,4-dioxane
5. customtransferred into a reactor
6. temperatureAfter the mixture was refluxed for 42 h
7. temperaturethe reaction mixture was then cooled to room temperature
8. customquenched with 50 mL of H2O
9. extractionextracted with 300 mL of diethyl ether
10. washThe organic extracts were washed with H2O (2×50 mL), brine (50 mL)
11. customdried over mgSO4
12. filtrationfiltered
13. customthe ether and dioxane removed from the filtrate by rotary evaporation
14. customThe resulting residue was chromatographed on silicon gel
15. concentrationThe eluate was concentrated by rotary evaporation

ORD record

ord-902e8822d59b49c9a9fc4c015310adf7

Source dataset

uspto-grants-2004_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06762330B2