Hydrochloric Acid → HCID 23508771, compound

HRID 1884274Notes

Reaction equation

HRID 1884274 reaction equation
C[O:2][C:3](=[O:47])[CH2:4][CH2:5][NH:6][C:7](=[O:46])[C:8]1[CH:13]=[CH:12][C:11]([C:14](=[O:45])[CH:15]([C:33]2[CH:38]=[CH:37][C:36]([CH:39]3[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]3)=[CH:35][CH:34]=2)[CH2:16][C:17]([C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=2)=[O:18])=[CH:10][CH:9]=1.Cl>C1COCC1>[F:26][C:25]([F:27])([F:28])[C:23]1[CH:24]=[C:19]([C:17](=[O:18])[CH2:16][CH:15]([C:33]2[CH:38]=[CH:37][C:36]([CH:39]3[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44]3)=[CH:35][CH:34]=2)[C:14]([C:11]2[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:47])=[O:2])=[O:46])=[CH:13][CH:12]=2)=[O:45])[CH:20]=[C:21]([C:29]([F:30])([F:31])[F:32])[CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86590585HCID 86590585, compound

Product 1

HCID 23508771HCID 23508771, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-{4-[4-(3,5-Bis-trifluoromethylphenyl)-2-(4-cyclohexylphenyl)-4-oxobutyryl]benzoylamino}propionic acid methyl ester (6.20 g, 9.38 mmol) was dissolved in THF (75 mL), HCl (6 N, 25 mL) was added and the mixture was heated to reflux, after 2 hours the heat was turned of and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated to dryness to give the title compound. Yield: quantitative.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux, after 2 hours the heat
  3. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-bd0e31f15a8a4c4095ebfe234300a2d7
Source dataset
uspto-grants-2004_07
Patent number
US06762318B2

Reaction notes

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