Acetone → HCID 19808496, compound

HRID 1885158Notes

Reaction equation

HRID 1885158 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.BrCC[C:22]1[CH:32]=[CH:31][CH:30]=[C:24]2[C:25]([NH:27][C:28](=[O:29])[C:23]=12)=[O:26].C(=O)([O-])[O-].[K+].[K+].[ClH:39].[CH3:40][C:41](C)=O>CCOCC>[ClH:39].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[N:13]2[CH2:14][CH2:15][N:16]([CH2:40][CH2:41][N:27]3[C:28](=[O:29])[C:23]4=[CH:22][CH:32]=[CH:31][CH:30]=[C:24]4[C:25]3=[O:26])[CH2:17][CH2:18]2)=[CH:5][CH:4]=1

Participants

7

Reactant 5

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 145667201-(7-Methoxynaphthalen-1-yl)piperazineHCID 219600212-Bromoethylphthalimide

Product 1

HCID 19808496HCID 19808496, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 1.5 g of (7-methoxy-1-naphthyl)piperazine and 1.5 g of (2-bromoethyl)phthalimide in 100 ml of acetone is brought to reflux in the presence of 1.6 g of potassium carbonate. The mixture is stirred for 24 hours. The mixture is cooled, it is concentrated. The oil obtained is ground in ether. The requisite quantity of ethereal hydrogen chloride is added to obtain the expected hydrochloride.

Workup

  1. temperatureThe mixture is cooled
  2. concentrationit is concentrated
  3. customThe oil obtained

Sources & evidence

ORD record
ord-9870f1cd142e497db91c864b63298c7e
Source dataset
uspto-grants-1992_09
Patent number
US05143916

Reaction notes

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