Potassium Acetate → HCID 10758857, compound

HRID 1885375Notes

Reaction equation

HRID 1885375 reaction equation
Br[CH2:2][C:3]1[CH:15]=[C:14]2[C:6]([C:7]3[CH:8]=[C:9]([Br:17])[CH:10]=[CH:11][C:12]=3[C:13]2=[O:16])=[CH:5][CH:4]=1.[C:18]([O-:21])(=[O:20])[CH3:19].[K+]>CN(C=O)C.C(OCC)(=O)C>[Br:17][C:9]1[CH:10]=[CH:11][C:12]2[C:13](=[O:16])[C:14]3[C:6]([C:7]=2[CH:8]=1)=[CH:5][CH:4]=[C:3]([CH2:2][O:20][C:18](=[O:21])[CH3:19])[CH:15]=3

Participants

5

Reactant 2

HCID 517044Potassium AcetateHCID 10665658HCID 10665658, compound

Product 1

HCID 10758857HCID 10758857, compoundYield 73.8%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
100 °C

Procedure

7-Bromomethyl-3-bromo-9-fluorenone (1.7 g) was suspended in DMF (25 ml). To this suspension was added potassium acetate (576 mg). The reaction mixture was stirred at 100° C. for one hour. It was then diluted with ethyl acetate, washed four times with water, twice with brine, dried and evaporated. The residue was chromatographed on silica gel using 2% ethyl acetate/methylene chloride and gave the desired product (1.18 g).

Workup

  1. washwashed four times with water
  2. dry with materialtwice with brine, dried
  3. customevaporated
  4. customThe residue was chromatographed on silica gel using 2% ethyl acetate/methylene chloride

Sources & evidence

ORD record
ord-70be80409f974b8c960549a9ef594261
Source dataset
uspto-grants-1992_09
Patent number
US05144028

Reaction notes

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