Hydrochloric Acid → HCID 67904724, compound

HRID 1885901Notes

Reaction equation

HRID 1885901 reaction equation
C[O:2][C:3]([CH2:5][CH2:6][CH2:7][S:8][CH:9]1[CH2:30][CH:12]2[N:13]([N:20]=[CH:21][CH:22]([CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[OH:23])[C:14](=[O:19])[N:15]([CH2:16][CH2:17][CH3:18])[CH:11]2[CH2:10]1)=[O:4].[OH-].[Li+].Cl.O>CO.O>[C:3]([CH2:5][CH2:6][CH2:7][S:8][CH:9]1[CH2:30][CH:12]2[N:13]([N:20]=[CH:21][CH:22]([CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[OH:23])[C:14](=[O:19])[N:15]([CH2:16][CH2:17][CH3:18])[CH:11]2[CH2:10]1)([OH:4])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 67904772HCID 67904772, compound

Product 1

HCID 67904724HCID 67904724, compoundYield 84.9%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
45 °C

Procedure

The compound of Example 1 (1.4 g) was dissolved in methanol:water (2:1, 10 ml) and to the stirred solution was added lithium hydroxide (0.267 g). The resulting mixture was maintained at 45° C. for one hour. The pH was adjusted to 5.0 with 2N HCl, water (50 ml) was added and the product was extracted into chloroform (50 ml). After drying over anhy. sodium sulphate, the mixture was filtered and the filtrate concentrated in vacuo to give the desired product (1.15 g).

Workup

  1. additionwas added
  2. extractionthe product was extracted into chloroform (50 ml)
  3. customAfter drying over anhy
  4. filtrationsodium sulphate, the mixture was filtered
  5. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-b617664f0cf44087b6567baedf9cbd0e
Source dataset
uspto-grants-1992_09
Patent number
US05147885

Reaction notes

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