Potassium Carbonate → HCID 15129665, compound

HRID 1885915Notes

Reaction equation

HRID 1885915 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]4[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:19]4=3)[C:14]3[C:9]2=[CH:10][C:11]([O:27][CH3:28])=[CH:12][CH:13]=3)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl.Cl[CH2:37][CH2:38][N:39]1[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1>CN(C)C=O>[CH3:26][O:25][C:23]1[CH:22]=[CH:21][C:19]2=[C:20]3[C:15](=[CH:16][CH:17]=[C:18]2[CH:24]=1)[C:14]1[C:9](=[CH:10][C:11]([O:27][CH3:28])=[CH:12][CH:13]=1)[CH:8]3[C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:37][CH2:38][N:39]2[CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]2)=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 74826Piperidine, 1-(2-chloroethyl)-, hydrochlorideHCID 15129664HCID 15129664, compound

Product 1

HCID 15129665HCID 15129665, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A 1.8 g portion of the compound of Example 3 was combined with 3.4 g of potassium carbonate, 0.95 g of 1-(2-chloroethyl)piperidine hydrochloride and 20 ml of dimethylformamide, and the reaction was carried out and the product was isolated as described above in Example 6. The chromatography gave 2.05 g of purified product, which was recrystallized from ethyl acetate/isooctane to obtain 1.93 g of highly purified product, m.p. 162°-164° C.

Workup

  1. customthe product was isolated

Sources & evidence

ORD record
ord-c2bbd118ce974390940e152d0d8dc66f
Source dataset
uspto-grants-1992_09
Patent number
US05147880

Reaction notes

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