反应详情

A mixture of 6-hydroxy-4-chromanone (18.6 g, 113 mmol), benzyl bromide (20 g, 116 mmol), and K2CO3 (21 g, 152 mmol) in acetone (110 ml) was refluxed for 20 hrs. The mixture was cooled, diluted with EtOAc, and filtered through celite. The filtrate was concentrated to an oil, which was triturated with 10% Et2O in hexane (150 ml) to gives, after filtration and washing, 28 g (87%) of the title compound.

1. temperaturewas refluxed for 20 hrs
2. temperatureThe mixture was cooled
3. filtrationfiltered through celite
4. concentrationThe filtrate was concentrated to an oil, which
5. customwas triturated with 10% Et2O in hexane (150 ml)
6. customto gives
7. filtrationafter filtration
8. washwashing