Triethylamine → HCID 11557656, compound

HRID 1886496Notes

Reaction equation

HRID 1886496 reaction equation
Br.[NH2:2][C@H:3]([C:8]([N:10]1[CH2:17][CH2:16][CH2:15][C@H:11]1[C:12]([NH2:14])=[O:13])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].C(N(CC)CC)C>CN(C=O)C>[NH2:2][C@H:3]([C:8]([N:10]1[CH2:17][CH2:16][CH2:15][C@H:11]1[C:12]([NH2:14])=[O:13])=[O:9])[CH2:4][CH:5]([CH3:6])[CH3:7]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 70044523HCID 70044523, compound

Product 1

HCID 11557656HCID 11557656, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
-10 °C

Procedure

L-Leucyl-L-prolinamide hydrobromide (517 mg) was dissolved in DMF (1.5 ml), to which was added triethylamine (0.35 ml) under cooling at -10° C. The mixture was stirred for 10 minutes under ice-cooling and the resultant precipitate was filtered off to give L-leucyl-L-prolinamide in DMF solution, which was immediately used for the next reaction.

Workup

  1. temperaturecooling
  2. filtrationthe resultant precipitate was filtered off

Sources & evidence

ORD record
ord-c7f6d573d3294e99a72d387976fe8093
Source dataset
uspto-grants-1992_09
Patent number
US05151497

Reaction notes

Loading…