Diisopropylethylamine → HCID 131730750, compound

HRID 1886843Notes

Reaction equation

HRID 1886843 reaction equation
[NH:1]([C:15]([O:17][CH2:18][CH:19]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]2[C:20]1=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:16])[C@H:2]([C:12]([OH:14])=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[B-](F)(F)(F)F.CN(C(O[N:45]1[C:50](=[O:51])[CH2:49][CH2:48][C:46]1=[O:47])=[N+](C)C)C.CCN(C(C)C)C(C)C>CN(C=O)C>[NH:1]([C:15]([O:17][CH2:18][CH:19]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]2[C:20]1=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:16])[C@H:2]([C:12]([O:14][N:45]1[C:50](=[O:51])[CH2:49][CH2:48][C:46]1=[O:47])=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 7017914Fmoc-O-benzyl-L-serineHCID 98575222-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate

Product 1

HCID 131730750HCID 131730750, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

FmocSer(Bzl) (1 mmol), TSTU (1 mmol), and DIEA (2 mmol) were dissolved in DMF (6 mL). The mixture was shaken at room temperature for half an hour. The solvent was evaporated to form FmocSer(Bzl)-OSu, which was used directly in the following steps.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-a55f0450ffed471897ded4bcad490ec8
Source dataset
uspto-grants-2013_08
Patent number
US08501498B2

Reaction notes

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