Triethylamine → 7-[(3-Chloro-2-methylphenyl)carbonyl]-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

HRID 1889111Notes

Reaction equation

HRID 1889111 reaction equation
[S:1]1[C:5]([C:6]2[N:10]3[CH2:11][CH2:12][NH:13][CH2:14][C:9]3=[N:8][N:7]=2)=[N:4][CH:3]=[N:2]1.C(N(CC)CC)C.[Cl:22][C:23]1[C:24]([CH3:32])=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26](Cl)=[O:27].C([O-])(O)=O.[Na+]>C(Cl)Cl.CO.C(OCC)(=O)C>[Cl:22][C:23]1[C:24]([CH3:32])=[C:25]([C:26]([N:13]2[CH2:12][CH2:11][N:10]3[C:6]([C:5]4[S:1][N:2]=[CH:3][N:4]=4)=[N:7][N:8]=[C:9]3[CH2:14]2)=[O:27])[CH:29]=[CH:30][CH:31]=1

Participants

8

Reactant 4

HCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 193677723-Chloro-2-methylbenzoyl chlorideHCID 66598795HCID 66598795, compound

Product 1

HCID 665989727-[(3-Chloro-2-methylphenyl)carbonyl]-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

Reagents, catalysts & solvents 3

HCID 887MethanolCatalystHCID 6344DichloromethaneSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine (I115) (50 mg, 0.240 mmol) and triethylamine (0.050 mL, 0.360 mmol) in DCM (1.5 ml) was treated with 3-chloro-2-methylbenzoyl chloride (I130) (49.9 mg, 0.264 mmol) in DCM (0.5 ml) and stirred at room temp for 1 h. After 1 h, 2 drops of methanol and then NaHCO3 solution (5 ml) and ethyl acetate (30 ml) were added. The product was extracted into the ethyl acetate which was dried (Na2SO4) and concentrated. Purification by high pH MDAP gave the desired product as a white solid in 66 mg.

Workup

  1. waitAfter 1 h
  2. extractionThe product was extracted into the ethyl acetate which
  3. dry with materialwas dried (Na2SO4)
  4. concentrationconcentrated
  5. customPurification by high pH MDAP

Sources & evidence

ORD record
ord-e1cb027e09b5438f8f38617992676255
Source dataset
uspto-grants-2013_08
Patent number
US08501946B2

Reaction notes

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