反应详情

Procedure-A: To a mixture of 2-(4-cyclopropanesulfonylphenyl)-2-(2,4-difluorophenoxy)acetic acid (obtained in step III), 2-aminothiazole, HOBt, and EDCI, in methylene chloride, was added triethyl amine. The resulting mixture was stirred at room temperature overnight followed by dilution with methylene chloride. The reaction mixture was poured into water; organic layer was washed with water, brine, dried over sodium sulfate, and the organic solvent evaporated to get a residue which was purified by preparative TLC or column chromatoghaphy to provide the title compound.

1. washorganic layer was washed with water, brine
2. dry with materialdried over sodium sulfate
3. customthe organic solvent evaporated
4. customto get a residue which
5. customwas purified by preparative TLC or column chromatoghaphy