Dimethylformamide → HCID 136348339, compound

HRID 1889453Notes

Reaction equation

HRID 1889453 reaction equation
[CH2:1]([C:3]1[S:23][C:6]2[NH:7][C:8](=[O:22])[N:9]([CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C)[C:10](=[O:11])[C:5]=2[CH:4]=1)[CH3:2].Br[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[C:38]2[N:42]=[C:41](C(Cl)(Cl)[Cl:44])[O:40][N:39]=2)=[CH:28][CH:27]=1.C(=O)([O-])[O-:48].[K+].[K+].CN(C)C=O>C(OCC)(=O)C>[ClH:44].[NH2:14][CH2:13][CH2:12][N:9]1[C:10](=[O:11])[C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[S:23][C:6]=2[N:7]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[C:38]3[NH:42][C:41](=[O:48])[O:40][N:39]=3)=[CH:28][CH:27]=2)[C:8]1=[O:22]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 15290996HCID 15290996, compoundHCID 59351734HCID 59351734, compound

Product 1

HCID 136348339HCID 136348339, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl [2-(6-ethyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)ethyl]carbamate (0.5 g), 3-[4′-(bromomethyl)biphenyl-2-yl]-5-(trichloromethyl)-1,2,4-oxadiazole (0.7 g), potassium carbonate (0.22 g) and N,N-dimethylformamide (20 mL) was stirred at room temperature for 2 hr. The reaction mixture was diluted with ethyl acetate, washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography and dissolved in tetrahydrofuran (5 mL) and methanol (5 mL). 1N Aqueous sodium hydroxide solution (5 mL) was added, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was adjusted to pH 7 with water and 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The obtained ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography and dissolved in ethyl acetate (5 mL). 4N Hydrochloric acid (ethyl acetate solution, 4 mL) was added, and the mixture was stirred at room temperature. The precipitated solid was collected by filtration to give the title compound as colorless crystals (0.12 g, 25%).

Workup

  1. washwashed successively with water and saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. customThe obtained residue was purified by silica gel column chromatography
  5. dissolutiondissolved in tetrahydrofuran (5 mL)
  6. addition1N Aqueous sodium hydroxide solution (5 mL) was added
  7. stirringthe mixture was stirred at room temperature for 2 hr
  8. extractionthe mixture was extracted with ethyl acetate
  9. washThe obtained ethyl acetate layer was washed with saturated brine
  10. dry with materialdried over anhydrous magnesium sulfate
  11. customThe solvent was evaporated under reduced pressure
  12. customThe residue was purified by silica gel column chromatography
  13. dissolutiondissolved in ethyl acetate (5 mL)
  14. addition4N Hydrochloric acid (ethyl acetate solution, 4 mL) was added
  15. stirringthe mixture was stirred at room temperature
  16. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-d70220b167d4432484d06405843ab928
Source dataset
uspto-grants-2013_08
Patent number
US08501750B2

Reaction notes

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