Hydrochloric Acid → Cariprazine

HRID 189001Notes

Reaction equation

HRID 189001 reaction equation
[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:34][N:35]([C:36](=[O:37])[Cl:38])[CH3:39].[Cl:40][CH2:41][Cl:42].[Cl:4][c:5]1[c:6]([N:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH:20]3[CH2:21][CH2:22][CH:23]([NH2:26])[CH2:24][CH2:25]3)[CH2:16][CH2:17]2)[cH:7][cH:8][cH:9][c:10]1[Cl:11].[ClH:1].[ClH:2].[ClH:3]>>[Cl:4][c:5]1[c:6]([N:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH:20]3[CH2:21][CH2:22][CH:23]([NH:26][C:36]([N:35]([CH3:34])[CH3:39])=[O:37])[CH2:24][CH2:25]3)[CH2:16][CH2:17]2)[cH:7][cH:8][cH:9][c:10]1[Cl:11]

Participants

6

Reactant 5

HCID 313Hydrochloric Acid3×HCID 6344DichloromethaneHCID 6598Dimethylcarbamoyl ChlorideHCID 8471TriethylamineHCID 44621617Cariprazine Impurity 3

Product 1

HCID 11154555Cariprazine

Sources & evidence

ORD record
ord-bf87d5b751a44cfcbd86e4bf2c288c51
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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