Dimethylformamide → 1-Boc-4-(4-ethynylphenyl)piperazine

HRID 189021Notes

Reaction equation

[CH3:21][Si:22]([CH3:23])([CH3:24])[C:25]#[CH:26].[Cu:27][I:28].[I:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1.[O:29]=[CH:30][N:31]([CH3:32])[CH3:33]>>[c:2]1([C:25]#[CH:26])[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 2795511Tert-butyl 4-(4-iodophenyl)piperazine-1-carboxylate

Product 1

HCID 866588361-Boc-4-(4-ethynylphenyl)piperazine

Sources & evidence

ORD record: ord-73cfb9086da240e09670b306720d94e1
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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