1-Hydroxybenzotriazole → HCID 46927105, compound

HRID 1891115Notes

Reaction equation

HRID 1891115 reaction equation
[CH3:1][N:2]1[C:7]2=[CH:8][S:9][C:10](C)=[C:6]2[C:5](=[O:12])[N:4]([CH3:13])[C:3]1=[O:14].[Br:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([NH2:28])[N:23]=2)=[CH:18][CH:17]=1.CCN=C=NC[CH2:35][CH2:36]N(C)C.Cl.C1C=CC2N([OH:50])N=NC=2C=1>CN(C1C=CN=CC=1)C.ClCCCl>[Br:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([NH:28][C:35](=[O:50])[CH2:36][C:7]3[C:6]4[C:5](=[O:12])[N:4]([CH3:13])[C:3](=[O:14])[N:2]([CH3:1])[C:10]=4[S:9][CH:8]=3)[N:23]=2)=[CH:20][CH:21]=1

Participants

7

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 45901504-(4-bromophenyl)pyrimidin-2-amineHCID 710080931,3,5-trimethylthieno[3,4-d]pyrimidine-2,4(1H,3H)-dione

Product 1

HCID 46927105HCID 46927105, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to the general procedure (Method A) by coupling Intermediate 1 (100 mg, 0.393 mmol) with 4-(4-bromophenyl)pyrimidin-2-amine (98 mg, 0.393 mmol) in the presence of EDCI hydrochloride (90 mg, 0.472 mmol), HOBt (16 mg, 0.118 mmol) and DMAP (5 mg, 0.039 mmol) in 1,2 dichloroethane (4 ml) to give 28 mg of the product as an off-white solid; 1H NMR (300 MHz, CF3 CO2 D) δ 3.57 (s, 3H), 3.77 (s, 3H), 4.45 (s, 2H), 7.18 (s, 1H), 7.80-7.86 (m, 2H), 8.06-8.18 (m, 3H), 8.64-8.70 (m, 1H); APCI-MS (m/z) 485.96 (M)+.

Sources & evidence

ORD record
ord-606f379c409849c0bdc9880a7fba635b
Source dataset
uspto-grants-2013_08
Patent number
US08507503B2

Reaction notes

Loading…