Hydrochloric Acid → {3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

HRID 1891240Notes

Reaction equation

HRID 1891240 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26].[ClH:27]>ClCCl.CO.C(O)(C)C>[ClH:27].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 44233767{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol

Product 1

HCID 44233766{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 130 mg of {3-[2-(2,4-difluorophenyl)-3-methylimidazo[1,2-α]pyridin-6-yl]phenyl}methanol in dichloromethane and methanol is passed through a frit and 3.7 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure. The residue obtained is triturated from diethyl ether and recovered by filtration and then oven-dried under reduced pressure. 128 mg of compound are obtained.

Workup

  1. additionare added to the filtrate
  2. concentrationThe reaction mixture is then concentrated under reduced pressure
  3. customThe residue obtained
  4. customis triturated from diethyl ether
  5. filtrationrecovered by filtration
  6. customoven-dried under reduced pressure

Sources & evidence

ORD record
ord-aab69326ba28499b866b5beeba3ca10a
Source dataset
uspto-grants-2013_08
Patent number
US08507520B2

Reaction notes

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