N-Hydroxyphthalimide → Methyl ((1,3-dioxo-1,3-dihydro-2H-isoindol-2-YL)oxy)acetate

HRID 1892295Notes

Reaction equation

[OH:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12].Br[CH2:14][C:15]([O:17][CH3:18])=[O:16]>>[O:12]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10](=[O:11])[N:2]1[O:1][CH2:14][C:15]([O:17][CH3:18])=[O:16]

Participants

Reactant 2

HCID 10665N-Hydroxyphthalimide

HCID 60984Methyl bromoacetate

Product 1

HCID 748410Methyl ((1,3-dioxo-1,3-dihydro-2H-isoindol-2-YL)oxy)acetateYield 56%

Procedure

The title compound was prepared from 2-hydroxyisoindoline-1,3-dione and methyl 2-bromoacetate in 56% yield using the same procedure as described in the synthesis of intermediate G. LCMS (method B): [MH]+=236, tR=1.82 min.

Sources & evidence

ORD record: ord-5411b31f73aa497db2eeff1b38d7d0ed
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08507676B2

Reaction notes

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