反应详情

39.2 g of benzyl phenyl ketone, 46.7 g of 1,2-dibromobenzene, g of palladium acetate, 10.5 g of triphenylphosphine, 77.2 g of cesium carbonate, and 400 mL of o-xylene were loaded into a flask, and the mixture was refluxed and stirred under heat under an argon atmosphere for 8 hours. After the completion of the reaction, the reaction solution was filtrated while being extracted with ether. The filtrate was dried with magnesium sulfate, and was then concentrated. The residue was purified by silica gel column chromatography, whereby 43.2 g of a white crystal were obtained (80% yield).

1. temperaturethe mixture was refluxed
2. temperatureunder heat under an argon atmosphere for 8 hours
3. customAfter the completion of the reaction
4. filtrationthe reaction solution was filtrated
5. extractionwhile being extracted with ether
6. dry with materialThe filtrate was dried with magnesium sulfate
7. concentrationwas then concentrated
8. customThe residue was purified by silica gel column chromatography