Hydrochloric Acid → HCID 68618629, compound

HRID 1893662Notes

Reaction equation

HRID 1893662 reaction equation
[CH3:1][O:2][C:3]([C:5]1([NH:11]C(OC(C)(C)C)=O)[CH2:7][CH:6]1[CH2:8][CH2:9][CH3:10])=[O:4].[ClH:19].O1CCOCC1>C1COCC1>[ClH:19].[CH3:1][O:2][C:3]([C:5]1([NH2:11])[CH2:7][CH:6]1[CH2:8][CH2:9][CH3:10])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 10682589HCID 10682589, compound

Product 1

HCID 68618629HCID 68618629, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-tert-butoxycarbonylamino-2-propyl-cyclopropanecarboxylic acid methyl ester (0.27 mmol) in THF (0.5 mL) was treated with 4M HCl in dioxane (2.4 mmol HCl). After 2 h, the volatiles are removed in vacuo to afford 1-amino-2-propyl-cyclopropanecarboxylic acid methyl ester hydrochloride salt as an amorphous white solid that was used without further purification (0.053 g, quant). LCMS found 157.9 ([M+H]+.

Workup

  1. customthe volatiles are removed in vacuo

Sources & evidence

ORD record
ord-f2534ba88e7d46c2991733bbaae7d8fc
Source dataset
uspto-grants-2013_08
Patent number
US08513186B2

Reaction notes

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