反应详情

温度

60 °C

To a solution of Compound 1c (52 mg; 0.213 mmol), acetyl chloride (46 mL, 0.647 mmol), bis(triphenyl)palladium(II)dichloride (4.49 mg, 0.0064 mmol) and copper (I) iodide (1.62 mg, 0.085 mmol) in anhydrous THF (5 mL), was added triethylamine (85 μL, 0.61 mmol) and the reaction mixture was stirred, in a closed vessel, at 60° C. for 5 h, cooled to r.t. poured into water and extracted with EtOAc. The combined extracts were washed with NaOH 0.1N, water, dried over Na2SO4 and evaporated to dryness in vacuo. Purification by flash chromatography (EtOAc—Petroleum Ether 25:75), afforded 17.5 mg of the title product.

1. temperaturecooled to r.t.
2. extractionextracted with EtOAc
3. washThe combined extracts were washed with NaOH 0.1N, water
4. dry with materialdried over Na2SO4
5. customevaporated to dryness in vacuo
6. customPurification by flash chromatography (EtOAc—Petroleum Ether 25:75)