反应详情

温度

-15 °C

To a cold (−15° C.) solution of Z-Glu-OMe (1.5 g) in THF (70 mL) was added N-methylmorpholine (0.616 mL) followed by isobutyl chloroformate (0.731 mL) dropwise. After 30 min stirring at −15° C., NaBH4 (576 mg) was added, followed MeOH dropwise. The reaction mixture was stirred at −10° C. for 15 min and quenched by the addition of 1M KHSO4 solution. The mixture was extracted with EA. The org. phase was washed with water, dried (Na2SO4) and evaporated off to give 1.5 g of the crude product as colorless oil.

1. stirringThe reaction mixture was stirred at −10° C. for 15 min
2. customquenched by the addition of 1M KHSO4 solution
3. extractionThe mixture was extracted with EA
4. washphase was washed with water
5. dry with materialdried (Na2SO4)
6. customevaporated off