Phosphorus oxychloride → HCID 86639256, compound

HRID 1896550Notes

Reaction equation

HRID 1896550 reaction equation
CO[C:3]1[C:15]2[C:14]3[CH:13]=[CH:12][C:11]([C:16]([F:19])([F:18])[F:17])=[CH:10][C:9]=3[N:8]([CH3:20])[C:7]=2[C:6]([C:21]#[N:22])=[CH:5][N:4]=1.C([O-])(O)=O.[Na+].O=P(Cl)(Cl)[Cl:30]>>[Cl:30][C:3]1[C:15]2[C:14]3[CH:13]=[CH:12][C:11]([C:16]([F:19])([F:18])[F:17])=[CH:10][C:9]=3[N:8]([CH3:20])[C:7]=2[C:6]([C:21]#[N:22])=[CH:5][N:4]=1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 516892Sodium BicarbonateHCID 68711881HCID 68711881, compound

Product 1

HCID 86639256HCID 86639256, compound

Procedure

A solution of the product from Step 1 in POCl3 (0.057 M) was set up on the Smith Creator microwave reactor for 10 min at 175° C. The resulting solution was poured onto cold saturated NaHCO3 solution and the suspension was stirred until all the reagent was consumed and the final pH was 7-8. The suspension was then filtered to give the title compound as an off-white solid.

Workup

  1. customwas consumed
  2. filtrationThe suspension was then filtered

Sources & evidence

ORD record
ord-eaaccad51ec54f25804e277d9a32f763
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

Loading…