反应详情

Under argon, 157.3 mg (3.6 mmol) of sodium hydride (55% suspension in mineral oil) were added to 620 mg (3.27 mmol) of 6-(2-fluorophenyl)pyridin-3-ol in 25 ml of DMF. After stirring at room temperature for 60 min, 551.4 mg (3.6 mmol) of bromoacetic acid methyl ester were added, and the reaction mixture was stirred at room temperature for 2 h. After concentrating, water was added, and the mixture was extracted with ethyl acetate. The organic phase was separated and concentrated. Yield: 687 mg (80%).

1. stirringthe reaction mixture was stirred at room temperature for 2 h
2. concentrationAfter concentrating
3. additionwater was added
4. extractionthe mixture was extracted with ethyl acetate
5. customThe organic phase was separated
6. concentrationconcentrated