Phenol → 4-Phenoxy-2,5-dimethylnitrobenzene

HRID 1896985Notes

Reaction equation

HRID 1896985 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:8][C:9]1[CH:14]=[C:13](Cl)[C:12]([CH3:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[O:7]([C:13]1[C:12]([CH3:16])=[CH:11][C:10]([N+:17]([O-:19])=[O:18])=[C:9]([CH3:8])[CH:14]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 996PhenolHCID 11430Potassium CarbonateHCID 2527931-Chloro-2,5-dimethyl-4-nitrobenzene

Product 1

HCID 685941194-Phenoxy-2,5-dimethylnitrobenzene

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4.44 g (47 mmol) of phenol and 8.76 g (47 mmol) of 2,5-dimethyl-4-chloro-nitrobenzene in 50 ml of DMF was admixed with 9.78 g (71 mmol) of K2CO3 and the mixture was heated under reflux for 10 h.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 10 h.

Sources & evidence

ORD record
ord-e30873f34018492d8853a23790373604
Source dataset
uspto-grants-2013_08
Patent number
US08519003B2

Reaction notes

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