反应详情

温度

50 °C

To methyl 5-bromonicotinate (3.0 g, 13.89 mmol) in TEA (50 mL) under N2 was added ethynyltrimethylsilane (5.83 mL, 41.7 mmol), copper(I) iodide (0.132 g, 0.694 mmol) and bis(triphenylphosphine)palladium(II) chloride (0.487 g, 0.694 mmol). The reaction was stirred at 50° C. for 1 h. The reaction was cooled to room temperature and filtered to remove the solids. The precipitate was washed thoroughly with ethyl acetate. The filtrate was then washed with water twice and extracted with ethyl acetate. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford a black color solid. Assuming 100% conversion this was taken on to next step for TMS removal. The crude was dissolved in MeOH (50 mL) and potassium carbonate (0.480 g, 3.47 mmol) was added to it. The reaction mixture was stirred for 30 min. The solids were filtered off, the filtrate was concentrated in vacuo. The crude was purified by silica gel flash chromatography using DCM-MeOH:90-10 to give pure product 5-Ethynyl-nicotinic acid methyl ester as a light yellow solid. ESI-MS: m/z 162.1 (M+H)+

1. temperatureThe reaction was cooled to room temperature
2. filtrationfiltered
3. customto remove the solids
4. washThe precipitate was washed thoroughly with ethyl acetate
5. washThe filtrate was then washed with water twice
6. extractionextracted with ethyl acetate
7. dry with materialThe organic layer was dried over sodium sulfate
8. concentrationconcentrated in vacuo
9. customto afford a black color solid
10. customthis was taken on to next step for TMS removal
11. dissolutionThe crude was dissolved in MeOH (50 mL)
12. stirringThe reaction mixture was stirred for 30 min
13. filtrationThe solids were filtered off
14. concentrationthe filtrate was concentrated in vacuo
15. customThe crude was purified by silica gel flash chromatography