Chloromethyl Methyl Ether → HCID 58268037, compound

HRID 1898249Notes

Reaction equation

HRID 1898249 reaction equation
[Br:1][C:2]1[C:7]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([CH2:19][CH3:20])[CH:13]=2)(=[O:11])=[O:10])=[CH:6][C:5]([Cl:21])=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:28][O:29][CH2:30]Cl>C1COCC1>[Br:1][C:2]1[C:7]([N:8]([CH2:28][O:29][CH3:30])[S:9]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([CH2:19][CH3:20])[CH:13]=2)(=[O:11])=[O:10])=[CH:6][C:5]([Cl:21])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 7864Chloromethyl Methyl EtherHCID 11430Potassium CarbonateHCID 58268262HCID 58268262, compound

Product 1

HCID 58268037HCID 58268037, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 2.35 g (5.73 mmol) of N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro-3-ethyl-benzenesulfonamide, 2.76 g of potassium carbonate and 1.3 mL of methoxymethyl chloride in 10 mL THF using procedure x. Yield: 980 mg of a white solid. LC-MSD, m/z for C15H15BrCl2N2O3S [M+H]+=452.9, 454.9, 456.9

Sources & evidence

ORD record
ord-36fad94c179740b29b3f3a9a6d85454d
Source dataset
uspto-grants-2013_08
Patent number
US08519135B2

Reaction notes

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