Chloromethyl Methyl Ether → HCID 58268053, compound

HRID 1898252Notes

Reaction equation

HRID 1898252 reaction equation
[Br:1][C:2]1[C:7]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([C:19]([F:22])([F:21])[CH3:20])[CH:13]=2)(=[O:11])=[O:10])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:30][O:31][CH2:32]Cl>C1COCC1>[Br:1][C:2]1[C:7]([N:8]([CH2:30][O:31][CH3:32])[S:9]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([C:19]([F:22])([F:21])[CH3:20])[CH:13]=2)(=[O:10])=[O:11])=[CH:6][C:5]([Cl:23])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 7864Chloromethyl Methyl EtherHCID 11430Potassium CarbonateHCID 58268115HCID 58268115, compound

Product 1

HCID 58268053HCID 58268053, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 460 mg (1.03 mmol) of N-(2-bromo-5-chloro-pyridin-3-yl)-4-chloro-3-(1,1-difluoro-ethyl)-benzenesulfonamide, 355 mg of potassium carbonate and 195 μL of methoxymethyl chloride in 2 mL THF using procedure x. Yield: 162 mg of a white solid. LC-MSD, m/z for C15H13BrCl2F2N2O3S [M+H]+=488.8, 490.8, 492.8; HPLC retention time: 2.9 min.

Sources & evidence

ORD record
ord-de9a57d6cd8b4e26949b46724f3dc4fe
Source dataset
uspto-grants-2013_08
Patent number
US08519135B2

Reaction notes

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