Hydrogen Peroxide → HCID 178507581, compound

HRID 1898315Notes

Reaction equation

HRID 1898315 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[OH:12]O>C(O)(=O)C>[NH2:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:8][N+:7]=1[O-:12]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 7358622-Amino-5-(trifluoromethyl)pyridine

Product 1

HCID 178507581HCID 178507581, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared by following the procedure described for Intermediate-40 using 5-(trifluoromethyl)pyridin-2-amine (0.500 g, 3.08 mmol), acetic acid (5.0 mL) and 50% hydrogen peroxide (2.0 mL) to afford 0.475 g of the desired product. 1HNMR (DMSO-d6): δ 6.88 (d, J=8.7 Hz, 1H), 7.40 (d, J=8.7 Hz, 1H), 7.49 (s, 2H), 8.49 (s, 1H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-0f7cf4e279b94ff2be69d32fe60b0f99
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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