Trolox → HCID 67263003, compound

HRID 1898694Notes

Reaction equation

HRID 1898694 reaction equation
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH3:31][N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([C:14]([N:35]1[CH2:36][CH2:37][N:32]([CH3:31])[CH2:33][CH2:34]1)=[O:16])([CH3:17])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 40634TroloxHCID 531671-MethylpiperazineHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 67263003HCID 67263003, compoundYield 83.4%

Procedure

Following the amide coupling procedure described in protocol A, 502 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.01 mmol), 354 mg CDI (2.18 mmol) and 220 mg N-methylpiprazine (2.2 mmol) produced 557 mg of (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-methylpiperazin-1-yl)methanone as a clear oil.

Sources & evidence

ORD record
ord-891c57be6e964d7e98ddd049b20293af
Source dataset
uspto-grants-2013_08
Patent number
US08519001B2

Reaction notes

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