HCID 67626277, compound → HCID 67626423, compound

HRID 1900012Notes

Reaction equation

HRID 1900012 reaction equation
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N:20]([C:22](=[O:39])[CH2:23][NH:24][C:25](=[O:38])[C@@H:26]4[CH2:30][CH2:29][CH2:28][N:27]4C(OC(C)(C)C)=O)[CH3:21])[C:14]=3[Cl:40])[C:5]2=[N:4][C:3]=1[CH3:41]>Cl.C(OCC)(=O)C>[ClH:19].[ClH:19].[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N:20]([C:22](=[O:39])[CH2:23][NH:24][C:25](=[O:38])[C@@H:26]4[CH2:30][CH2:29][CH2:28][NH:27]4)[CH3:21])[C:14]=3[Cl:40])[C:5]2=[N:4][C:3]=1[CH3:41]

Participants

4

Reactant 1

HCID 67626277HCID 67626277, compound

Product 1

HCID 67626423HCID 67626423, compoundYield 298.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

3-Bromo-8-[3-[N-(tert-butoxycarbonyl-L-prolylglycyl)-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylimidazo[1,2-a]pyridine (67 mg) was dissolved in 4N solution of hydrogen chloride in ethyl acetate (3 ml). The solution was evaporated in vacuo to give 3-bromo-8-[2,6-dichloro-3-[N-(L-prolylglycyl)-N-methylamino]benzyloxy]-2-methylimidazo[1,2-a]pyridine dihydrochloride (64 mg) as colorless glass.

Workup

  1. customThe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-fce166de6f4f46708ea43c7958c24e76
Source dataset
uspto-grants-1996_11
Patent number
US05574042

Reaction notes

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