反应详情

A mixture comprising 339 mg of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline, 500 mg of 4-hydroxypiperidine and 20 ml of N,N-dimethylformamide was heated under reflux for 5 hours and poured into 50 ml of water, followed by the addition of 50 ml of ethyl acetate. The obtained mixture was filtered to remove insolubles. The organic layer of the filtrate was dried over magnesium sulfate and concentrated under a reduced pressure to give a crystalline residue. This residue was washed with chloroform to give 145 mg of the title compound.

1. temperaturewas heated
2. temperatureunder reflux for 5 hours
3. filtrationThe obtained mixture was filtered
4. customto remove insolubles
5. dry with materialThe organic layer of the filtrate was dried over magnesium sulfate
6. concentrationconcentrated under a reduced pressure
7. customto give a crystalline residue
8. washThis residue was washed with chloroform