反应详情

3.5 g of ethyl isonipecotate, 2.25 g of triethylamine and 30 ml of 2-propanol were added to 1 g of 2-chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline. The obtained mixture was refluxed for 30 minutes and cooled to room temperature. The crystals thus precipitated were recovered by filtration and washed with water and ethanol successively to give 1.13 g of the title compound.

1. temperatureThe obtained mixture was refluxed for 30 minutes
2. customThe crystals thus precipitated
3. filtrationwere recovered by filtration
4. washwashed with water and ethanol successively