反应详情

温度

70 °C

5-Hydroxy-3,8-dimethylcarbostyril (4 g, 21.16 mmol) and allyl iodide (3.73 g, 22.2 mmol) were dissolved in dimethylformamide (44 ml), to which potassium carbonate (6.1 g, 44.2 mmol) was added, and stirred for 2 hours in a bath at 70° C. The solvent was distilled off, and the residue was dissolved in chloroform, and washed with water. After drying and condensing, the resultant residue was purified by silica gel chromatography (chloroform), and was subjected to recrystallization (chloroform-n-hexane) to obtain 4.32 g of the title compound as pale yellow prisms (89.2%).

1. additionwas added
2. distillationThe solvent was distilled off
3. dissolutionthe residue was dissolved in chloroform
4. washwashed with water
5. customAfter drying
6. customcondensing
7. customthe resultant residue was purified by silica gel chromatography (chloroform)
8. customwas subjected to recrystallization (chloroform-n-hexane)