Hydrochloric Acid → HCID 67733446, compound

HRID 1901639Notes

Reaction equation

HRID 1901639 reaction equation
[NH2:1][C@@H:2]([CH2:15][S:16]([CH3:18])=[O:17])[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1.CC(O)C.Cl>C(Cl)Cl>[ClH:14].[NH2:1][C@@H:2]([CH2:15][S:16]([CH3:18])=[O:17])[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 67733447HCID 67733447, compound

Product 1

HCID 67733446HCID 67733446, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.14 g of (R)-3-(2-amino-3-methanesulfinylpropoxy)-5-chloro-1,2-benzoisoxazole in 2 ml of methylene chloride is added 0.4 ml of a 2-propanol solution (6.5M) of hydrogen chloride, and the crystals precipitated are collected by filtration, to obtain 0.07 g of colorless, crystalline (R)-3-(2-amino-3-methanesulfinylpropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride.

Workup

  1. customthe crystals precipitated
  2. filtrationare collected by filtration

Sources & evidence

ORD record
ord-9c07d1433e874a5b950dec9fe373fb7f
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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