Hydrochloric Acid → HCID 67733471, compound

HRID 1901640Notes

Reaction equation

HRID 1901640 reaction equation
[NH2:1][C@@H:2]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1.CC(O)C.Cl>C(Cl)Cl>[ClH:14].[NH2:1][C@@H:2]([CH2:15][S:16]([CH3:19])(=[O:17])=[O:18])[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 67733472HCID 67733472, compound

Product 1

HCID 67733471HCID 67733471, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 0.38 g of (R)-3-(2-amino-3-methanesulfonylpropoxy)-5-chloro-1,2-benzoisoxazole in 4 ml of methylene chloride is added 1 ml of a 2-propanol solution (6.5M) of hydrogen chloride, and the crystals precipitated are collected by filtration, to obtain 0.22 g of colorless, crystalline (R)-3-(2-amino-3-methanesulfonylpropoxy)-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 189.9°-192.5° C. (decomp.).

Workup

  1. customthe crystals precipitated
  2. filtrationare collected by filtration

Sources & evidence

ORD record
ord-f4e7cebd8b9041a080b6d0366fd7ebea
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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