Dimethylformamide → HCID 20514575, compound

HRID 1902639Notes

Reaction equation

HRID 1902639 reaction equation
[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[CH:10][C:11]([NH2:13])=[CH:12][C:7]=3[S:6][C:5]=12.[Br:14]C(C)(C)C.CN(C)[CH:21]=[O:22]>O>[BrH:14].[N:1]1[CH2:2][CH2:3][N:4]2[C:8]3[CH:9]=[CH:10][C:11]([NH:13][CH:21]=[O:22])=[CH:12][C:7]=3[S:6][C:5]=12

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 10485t-Butyl bromideHCID 12892043Imidazo[2,1-b]benzothiazol-7-amine, 2,3-dihydro-

Product 1

HCID 20514575HCID 20514575, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3 parts of 2,3-dihydroimidazo[2,1-b]benzothiazol-7-amine, 15 parts of 2-bromo-2-methylpropane and 13.5 parts of N,N-dimethylformamide is stirred for 20 hours at 80° C. The reaction mixture is poured onto 50 parts of water. The precipitated product is filtered off, washed successively with water, 2-propanol and 2,2'-oxybispropane, and dried, yielding 3 parts of N-(2,3-dihydroimidazo[2,1-b]benzothiazol-7-yl)formamide monohydrobromide; mp. 287.3° C.

Workup

  1. filtrationThe precipitated product is filtered off
  2. washwashed successively with water, 2-propanol and 2,2'-oxybispropane
  3. customdried

Sources & evidence

ORD record
ord-ca7c55c5e31c4dbdb335af491f9001e3
Source dataset
uspto-grants-1982_12
Patent number
US04364942

Reaction notes

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