1-Bromohexadecane → HCID 12886752, compound

HRID 1902876Notes

Reaction equation

HRID 1902876 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[CH:3]=1.Br[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:28]([O:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[O:8][C:4]=2[CH:3]=1)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH3:13]

Participants

5

Reactant 3

HCID 82131-BromohexadecaneHCID 11430Potassium CarbonateHCID 6765042-Methyl-1,3-benzoxazol-6-ol

Product 1

HCID 12886752HCID 12886752, compoundYield 100.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

18.0 g of 6-hydroxy-2-methylbenzoxazole synthesized from Synthesis 1, 36.6 g of 1-bromohexadecane, 24.0 g of potassium carbonate and 120 ml of N,N-dimethylformamide were mixed with stirring at 90° C. for 4.5 horus. Solids were removed from the reacting solution, and the filtrate was poured into 500 ml of methanol. The separated crystals were separated by filtration to obtain 45.0 g of 6-hexadecyloxy-2-methylbenzoxazole.

Workup

  1. additionwere mixed
  2. customSolids were removed from the reacting solution
  3. additionthe filtrate was poured into 500 ml of methanol
  4. customThe separated crystals were separated by filtration

Sources & evidence

ORD record
ord-2a3af5d4e92e441db66278a20e5bac2f
Source dataset
uspto-grants-1982_12
Patent number
US04366226

Reaction notes

Loading…