2-Chloro-4,5-dihydroimidazole → HCID 13255561, compound

HRID 1903577Notes

Reaction equation

HRID 1903577 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2.[Cl:12][C:13]1[NH:14][CH2:15][CH2:16][N:17]=1>C1COCC1.CCOCC>[ClH:12].[NH:17]1[CH2:16][CH2:15][N:14]=[C:13]1[NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2

Participants

5

Reactant 2

HCID 2362362-Chloro-4,5-dihydroimidazoleHCID 27680321-methyl-1H-indazol-5-amine

Product 1

HCID 13255561HCID 13255561, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

5-amino-1-methyl-indazole is dissolved in absolute THF and treated with a solution of an equimolar quantity of 2-chloro-imidazoline in ether. The mixture is stirred for 48 hours in a darkened, sealed flask at room temperature. The precipitated reaction product is separated and recrystallized from ethanol. The purified, white, crystallized hydrochloride has a melting point from 240° to 241° C.

Workup

  1. customsealed flask at room temperature
  2. customThe precipitated reaction product
  3. customis separated
  4. customrecrystallized from ethanol
  5. customThe purified, white, crystallized hydrochloride
  6. customfrom 240° to 241° C.

Sources & evidence

ORD record
ord-038779f0258847959f2af2be5eaf2925
Source dataset
uspto-grants-1984_03
Patent number
US04436913

Reaction notes

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