反应详情

To a sodium ethoxide solution prepared with sodium metal (460 mg) and anhydrous ethanol (50 ml) was added 2-bromo-4-phenoxybenzothiazole (3.0 g). The mixture was refluxed with stirring 45 minutes. The solvent was removed under reduced pressure to give a residue, to which was added 10% hydrochloric acid (30 ml) and acetone (50 ml). The resultant mixture was refluxed with stirring for 2 hours. The solvent was removed under reduced pressure to give a residue, which was recrystallized from a mixture of ethanol and n-hexane to give crystalline 2-oxo-4-phenoxybenzothiazoline (2.0 g).

1. temperatureThe mixture was refluxed
2. customThe solvent was removed under reduced pressure
3. customto give a residue
4. stirringwith stirring for 2 hours
5. customThe solvent was removed under reduced pressure
6. customto give a residue, which
7. customwas recrystallized from a mixture of ethanol and n-hexane