Hydrochloric Acid → HCID 178461711, compound

HRID 1906653Notes

Reaction equation

HRID 1906653 reaction equation
[ClH:1].[C:2]1([CH:8]2[CH2:10][N@:9]2[C@@H:11]([CH3:23])[CH2:12][CH2:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C>[ClH:1].[ClH:1].[C:2]1([CH:8]2[CH2:10][N@:9]2[C@@H:11]([CH3:23])[CH2:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:18]([NH2:20])=[O:19])=[CH:21][CH:22]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178461710HCID 178461710, compound

Product 1

HCID 178461711HCID 178461711, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 0.87 g of hydrogen chloride in 20 ml of ethyl acetate was added dropwise at 5°, while stirring, to a solution of 3.1 g of p-[(S)-3-[(S)-2-phenyl-1-aziridinyl]butyl]benzamide in 150 ml of ethyl acetate. The precipitate was filtered off under suction and recrystallized from methanol/ether. There was obtained pure p-[(S)-3-[(S)-2-phenyl-1-aziridinyl]butyl]benzamide dihydrochloride of melting point 186°-188°.

Workup

  1. filtrationThe precipitate was filtered off under suction
  2. customrecrystallized from methanol/ether

Sources & evidence

ORD record
ord-b8729e08ccdb4a63a061fae061a946ae
Source dataset
uspto-grants-1987_03
Patent number
US04652679

Reaction notes

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